Epithelial to mesenchymal transition: new and old insights from the classical neural crest model.
نویسندگان
چکیده
The epithelial-to-mesenchymal transition (EMT) is an important event converting compact and ordered epithelial cells into migratory mesenchymal cells. Given the molecular and cellular similarities between pathological and developmental EMTs, studying this event during neural crest development offers and excellent in vivo model for understanding the mechanisms underlying this process. Here, we review new and old insight into neural crest EMT in search of commonalities with cancer progression that might aid in the design of specific therapeutic prevention.
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عنوان ژورنال:
- Seminars in cancer biology
دوره 22 5-6 شماره
صفحات -
تاریخ انتشار 2012